同济大学干细胞和系统生物学实验室副教授/副研究员、助理教授/究员、博士后、博士和硕士生及技术员招聘 工作地点： 上海 招聘人数： 4-8人 联系人：高正良 EMAIL：
zhengliang_gao@tongji.edu.cn 实验室主要方向：干细胞生物学、表观遗传学和转分化、重编程；神经再生与退行性疾病；基因工程与基因治疗、组织器官工程与再生治疗；神经肿瘤生物学与个体化治疗。相关工作发表于Nature Neuroscience, Nature Chemical Biology, Journal of Neuroscience等国际一流期刊。目前实验室已经建立了比较完善的研究体系和技术基础和团队，目前实验室有助理教授2人，博士后2人，博士2人，硕士3人，研究助理2人，联合培养和进修人员5人，开展了很多的前期工作，可以提供多个相关但独立，风险性高低结合的课题和方向；对有志于科研或希望将来获取独立职位的实验室人员，本研究室将给予自由发展空间，尽最大程度提供职业锻炼，成长的机会，并帮助，鼓励发展独立课题。管理方面，本实验室将力求做到求同存异，人尽其才，人尽其用，人尽其得，为实验人员创造一个严谨宽松，松弛有度，公正和谐，共同发展的研究和职业成长环境。看了这些梦语版的话，如果有一点共鸣，那么请来信，也许你就是我要寻找的，可以一起做事的同仁。 主要研究方向和课题： 1.结合组学技术，运用整合生物信息学和系统生物学研究手段解析神经干细胞静息、激活与分化及在神经发育、可塑性， 脑的动态平衡，疾病的产生和再生修复过程中的功能与机理，绘制静息激活和分化的表观遗传学调控图谱。 2.完善体外神经干细胞和肿瘤干细胞的二维和三维培养体系、高通量功能和药物筛选技术，结合大小鼠和单细胞遗传学技术、异种移植（exnograft）对组学水平上的结果开展功能性验证和疾病模拟及个体化治疗的探索。 3.三维打印、三维细胞骨架、组织器官工程和器官重建与重大疾病的模拟、药物研发和再生治疗。 4.REST 及 RNA生物学（包括lncRNA, miRNA, eRNA以及RNA剪切和编辑等）在神经可塑性、疾病和再生修复中的功能与机理（包括学习记忆、神经损伤、心理和退行性疾病等）； 5.探索利用高通量技术和系统生物学手段指导个体化、动态的疾病诊疗和病人健康管理的方案。 6. 脂肪干细胞生物学、转分化、重编程与临床应用。 应聘条件： 1.背景不是第一要素，首要的是做人，性格，团队精神，自律性和良好习惯：希望工作踏实，认真细心，愿意学习新东西；有较强的责任心、上进心、敬业和团队精神，对做科研、实验室或临床转化工作有激情。 2.较好的英语阅读、写作和交流能力，动手和学习能力强。 3.博士后时间（可达2-4年），年薪可以在12-15以上，外加绩效奖金；需要有较好的研究背景和独立工作的能力，第一作者至少发过较高水平的研究性文章（单篇3-4分以上，或者总共6-7分以上）。 4. 根据学校要求，副教授和助理教授的候选人需要本科、博士均985毕业，非985学校，需要或者有过博士后经历，或者博士毕业于国外较知名大学和研究机构，并拥有较强的研究背景和发表记录（具体需参照学校的支撑评定标准—真正有潜力和学校和发表背景尚待完善的人可以考虑助理研究员途径）,助理教授年薪在8-12万元以上，有编制和各种福利待遇和绩效奖金，可以2个任期共6年，任期内（1-6年）必须有重要产出升职副教授或教授。 5.任何生命科学背景的都欢迎，特别是有相关研究技术知识背景的包括组学和高通量技术；单细胞分析技术和活细胞实时成像；转基因，基因组编辑、病毒载体构建和制备，活体注射和电转；动物和疾病模型建立；干细胞生物学、营养代谢生物学、细胞生物学，分子生物学，发育生物学，神经生物学，遗传学，生物信息，系统生物学和组织工程等。 6.具有较强数学，统计学，计算，物理或工程背景而且对生物学有强烈兴趣和一定了解和背景的也欢迎。 应聘者请将应聘材料（个人中英文简历，联系方式，研究学习背景介绍，未来研究兴趣与职业目标以及2-3个推荐人的联系方式）以单一文件（pdf）发送至
zhengliang_gao@tongji.edu.cn；应聘者的申请材料将会被严格保密。待遇将根据申请人的资历背景，参照相关人事政策 从优，薪酬面议。 You can also attach this english version to the Ad: Key words: Neural development and diseases; Brain tissue engineering; 3D neural development and extracellular matrix; Neural stem cell quiescence and activation; Transcriptional/epigenetic network; Genomics and Systems Biology; REST/NRSF; Reprogramming and trans-differentiation; Regenerative medicine, genome editing, metabolic management and disease control Summary: Stem cells are remarkable in their ability to cooperate to form and maintain tissues with proper size and function during development and throughout life. At the Stem Cell and Systems Biology Group, we focus on central nervous system (CNS): 1) how human CNS develops and 2) how brain homeostasis and plasticity are maintained and regulated. Not only do we like to dissect the development and homeostasis, but also we wish to model diseases and to develop potential therapeutics in collaborations with clinicians. Integral to our research are the concept of networks, dynamics and homeostasis, and the use of inter-discipline approaches (e.g.: molecular genetics, tissue engineering, single cell analyses, genomics, bioinformatics, systems biology and mathematic modeling). On one hand, we perform non-hypothesis driven experimentations and analyses to deduce the core principles of an interested system; on the other hand, we let the data lead us and focus on specific hypotheses and potentially crucial machineries. Finally, we research innovative strategies to restore the homeostasis of a concerned entity. Specific interest areas: 1: Brain Engineering: Animal models are bound with the inability to model human specific development and diseases. Seminal works from the late Dr. Sasai and others highlight the intrinsic potential of stem cells to self-organize and form “organoids” in vitro. In light of successful in vitro reconstruction of major organs including heart, liver, lung and kidney, we have embarked on stem cell engineering of brain. We hope to utilize this approach to elucidate the 3-dimention principles of CNS development and diseases, and how extracellular matrix (ECM) etc regulates and adapts to them, and how to utilize ECM scaffold and/or brain “tissueoid” for regenerative therapy. 2. Neural Stem Cell (NSC) Quiescence and Activation: Resident stem cells maintain tissue homeostasis, constitute an extraordinary example of tissue plasticity, and contribute to repair and regeneration. The quiescence and activation of resident stem cells holds the key for stem cell maintenance and tissue homeostasis. But, largely due to technical challenges, the quiescence and activation of stem cells at most of organ sites remains poorly studied. We have developed in vitro model systems to evade the technical hurdles and a major goal of our lab is to model and explore cellular and mathematic/physical properties of NSC quiescence and activation, and to define molecular frameworks (e.g.: transcriptional/epigenetic networks) underlying normal and disease states. Insights gathered so far are leading us to explore metabolic/nutrient strategies to manipulate adult neurogenesis and brain function (e.g.: learning and memory) in physiological, aging and neurodegenerative settings. 3. REST/NRSF in the Control of Neuron Activity and Plasticity: Besides its roles governing neural development, stem cell quiescence and adult neurogenesis, work from ours and others strongly suggests that REST likely plays a major role in neuron activity and plasticity. Working with conditional REST knockout mouse alleles, we are taking both genetic and genomic approaches to dissect the function and molecular networks of REST in specific neuronal types. 4. Reprogramming and Trans-differentiation towards Neural Lineages: we are interested: 1) to understand reprogramming mechanisms and 2) to develop highly efficient trans-differentiation approaches practical for generating enough directed neural stem/progenitor cells of potential clinical usage. 5. Translational Medicine: To build upon the basic side of our work and that of others, we are actively thinking and pursuing innovative strategies for stem cell therapies, genome editing and nutrient/metabolic management of disease states.
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